Influence of nanocrystalline cerium dioxide on antigens of non-specific protection of quails

Intensive poultry farming technologies are closely linked to a variety of environmental, technological, feed and biological stressors, which tend negatively affect their productivity immune defenses. In the pathogenesis such detrimental effects, leading role belongs overproduction oxygen free radicals - oxidative stress. The latter activates number transcription factors, including Nrf-2 Nf-kB, modulate antioxidant defense network participate in organization infection control. NDC is able reduce activation Nf-kB thus maintain balance, but response system this factor insufficiently studied. aim our work investigate effect on antigen non-specific immunity quails by adding it drinking water. object study were quail Pharaoh breed, experimental control groups formed at age one day principle analogues. birds kept cages with access food Quails group water was added additive Nanocerium dose 8.6 mg per liter This an aqueous dispersion average nanoparticle size 2-7 nm. weight end experiment (56 days) 20.2 g greater than Morphometric studies thymus, bursa spleen showed no central peripheral systems. Morphological parameters blood within physiological norm, erythrocytes hemoglobin content higher. leukocyte count increase (according Garkavi LH) group. Humoral performance identical both groups. Studies cellular indicate phagocytic function peripheralblood cells. Functional metabolic activity under influence spontaneous test probably did not differ increased stimulated. Therefore, that received nanocerium had higher immunoresistance. Key words: birds, nanocerium, morphometry, natural immunity, morphological blood, hematopoiesis, humoral hematological parameters. Accepted abbreviations: – nanocrystalline cerium dioxide, ROS reactive species, nuclear kV, erythroid 2 related 2.